I have been running VMware on Intel for over 10 years now. It is comfortable and reliable. However, over the last few years I also had to patch multiple Intel vulnerabilities. Meltdown and Spectre patches, released in 2017, were known to impact performance. Then a L1 Terminal Fault was discovered and VMware started recommending customers disable Hyper-Threading.
It was time to try something new. This year, I had a chance to refresh our server infrastructure. I had already upgraded my laptop to a Ryzen 7 Pro. The AMD EPYC 7502 is exciting with 32 cores per processor and great benchmarks. We previously had processors with 16 and 20 cores. This many cores per processor would allow us to downsize and save money on licensing.
It has been three months now and everything is working great. The majority of the company is unaware that we migrated, let alone, to a new CPU architecture.
The only gotcha when moving from Intel to AMD is that the virutal machines need to be powered off before vMotion. This did slow down migrating almost 300 hundred virtual machines, but I used this opportunity to upgrade VM compatibility and VMware tools.
I would recommend everyone consider switching.